| Expression pattern: |
UP |
| Associated gene: |
PFN2, AGO2, DLG1 |
| Associated microRNA: |
miR-758-3p |
| Biological function: |
circ_0008500 promotes breast cancer cell growth, proliferation, tumor growth and radioresistance, while inhibiting apoptosis; knockdown of circ_0008500 enhances radiosensitivity and suppresses tumorigenesis. |
| Molecular mechanism: |
circ_0008500 acts as a competing endogenous RNA that sponges miR-758-3p to upregulate PFN2 expression, thereby promoting breast cancer development and reducing radiosensitivity. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0008500 is upregulated in breast cancer tissues and shows different expression across TNBC and ER/PR status, suggesting potential relevance to breast cancer development and radiosensitivity. |
| Description: |
hsa_circ_0008500/circ_0008500 is upregulated in breast cancer tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses cell viability, proliferation, colony formation and xenograft tumor growth, promotes apoptosis, and enhances radiosensitivity. Mechanistically, circ_0008500 sponges miR-758-3p to regulate PFN2 expression through a circ_0008500/miR-758-3p/PFN2 axis. |
| Confidence score: |
0.8442 |