| Expression pattern: |
UP |
| Associated gene: |
Notch1, c-Myc, cyclin D1, MMP-2, MMP-9, Hes1, Jagged1 |
| Associated microRNA: |
miR-101-3p / miR-101 |
| Biological function: |
Promotes colorectal cancer cell proliferation, migration, invasion, tumour growth and liver metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circAPLP2 functions as a miR-101-3p sponge to upregulate Notch1 and activate the Notch signalling pathway, increasing proliferation- and metastasis-related proteins. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
circAPLP2 may serve as a potential biomarker and therapeutic target for CRC. |
| Description: |
circAPLP2 is upregulated in colorectal cancer tissues and cells. It promotes CRC proliferation, migration, invasion, tumour growth and liver metastasis by sponging miR-101-3p, increasing Notch1 expression and activating Notch signalling-associated proliferation and metastasis proteins. |
| Confidence score: |
0.7132 |