| Expression pattern: |
UP |
| Associated gene: |
FGFR2, CyclinD1, MMP9 |
| Associated microRNA: |
miR-204-5p |
| Biological function: |
Promotes GBC cell proliferation, viability, migration, invasion and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ_0008234 acts as a ceRNA/miRNA sponge targeting miR-204-5p to regulate FGFR2 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
circ_0008234 expression was closely associated with TNM stage, lymph node metastasis and tumor size; the study suggests circ_0008234 may be a biomarker or therapeutic target for GBC. |
| Description: |
hsa_circ_0008234/circ_0008234 is up-regulated in gallbladder carcinoma tissues and cell lines and is associated with TNM stage, lymph node metastasis and tumor size. Functionally, circ_0008234 promotes malignant GBC phenotypes including proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it mainly acts through a ceRNA axis by targeting miR-204-5p and regulating FGFR2 expression. |
| Confidence score: |
0.7861 |