circRNA basic information
circBase ID: hsa_circ_0001400
Name: hsa_circ_RELL1
Synonym: circRELL1 / circ_0001400
Host Gene: RELL1
Genomic location(hg19): chr4:37633006-37640126:-
Genomic location(hg38): chr4:37631384-37638504:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004609
MONDO name: herpes simplex infectious disease
Disease details: Herpes simplex virus-1 / HSV-1 lytic infection
Disease DO ID:
 8566
Disease MeSH ID:
 D006561
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

trigeminal ganglia
Cell lines:

MRC-5; 293T; iSLK-BAC16; Vero; Akata; BJAB; Daudi; NIH 3T3; NIH 3T12; A20 HE-RIT; HDLEC; LEC
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: TTI1 mRNA
Associated microRNA: -
Biological function: suppresses lytic infection and reduces infectious viral yield in HSV-1 infection
Molecular mechanism: interacts with TTI1 mRNA; mechanism not fully understood
Biological pathway or process:

viral replication (inhibits); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Transfection; In Vivo Animal Model
Clinical significance:

-
Description:

circRELL1 (hsa_circ_0001400) is induced during herpesvirus infection and by interferon stimulation. In HSV-1 lytic infection, circRELL1 restricts production of infectious progeny, supported by siRNA knockdown and lentiviral overexpression experiments; it may act in part via interaction with TTI1 mRNA, though the mechanism is not fully defined.
Confidence score:

0.4062
Other information
Title:

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.

Journal: EMBO reports
Published: 2024
PubMed ID: 38263330
Study type:

combined biological and clinical study
Data availability: SRA: SRP383035; SRP383161; SRP383241; SRP385335; SRP383239; SRP458394; GEO: GSE206824
Code availability: -