| Expression pattern: |
UP |
| Associated gene: |
NLRP3, KAT2B, NLRP3 inflammasome complex, ASC |
| Associated microRNA: |
- |
| Biological function: |
CircAR-3 promotes inflammatory response, prostate cancer cell proliferation, NLRP3 inflammasome stability and assembly, and prostate cancer progression. |
| Molecular mechanism: |
CircAR-3 activates the NLRP3 inflammatory pathway by mediating KAT2B-dependent acetylation modification of NLRP3 and promoting subcellular distribution, stability, and assembly of the NLRP3 inflammasome complex. |
| Biological pathway or process: |
inflammation (promotes); proliferation (promotes); immune regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; Western Blot; Co-IP; IF (Immunofluorescence); Colony Formation Assay; MTT; In Vivo Animal Model |
| Clinical significance: |
CircAR-3 is upregulated in high-grade PCa tissues and may represent a target within the NLRP3 acetylation/inflammasome assembly pathway for inhibiting PCa progression. |
| Description: |
CircAR-3 (hsa_circ_0090925) is a human AR-derived circRNA upregulated in high-grade prostate cancer. It promotes PCa inflammatory responses and cell proliferation by enhancing KAT2B-mediated NLRP3 acetylation and stabilizing/assembling the NLRP3 inflammasome complex. |
| Confidence score: |
0.7907 |