| Expression pattern: |
DN |
| Associated gene: |
RASA1, Ago2 |
| Associated microRNA: |
miR-421 |
| Biological function: |
Inhibits TNBC cell proliferation, migration, invasion, tumor growth, and lung metastasis. |
| Molecular mechanism: |
circAHNAK1 functions as a ceRNA by sponging miR-421, thereby relieving miR-421-mediated repression of RASA1. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; Survival Analysis; ROC Analysis; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
circAHNAK1 expression was negatively correlated with larger tumors, positive lymph node metastasis, and late TNM stage; low expression predicted poor OS and DFS; ROC analysis suggested diagnostic value distinguishing TNBC from normal breast tissue. |
| Description: |
circAHNAK1 is down-regulated in TNBC and acts as a tumor-suppressive circRNA. It mainly localizes in the cytoplasm and functions as a ceRNA that sponges miR-421 to increase RASA1 expression, thereby inhibiting TNBC proliferation and metastasis and associating with better patient survival when highly expressed. |
| Confidence score: |
0.8718 |