| Expression pattern: |
UP |
| Associated gene: |
ABCC1 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
circPVT1 promotes cisplatin and pemetrexed chemotherapy resistance in lung adenocarcinoma; knockdown of circPVT1 sensitizes A549/DR cells to cisplatin and pemetrexed. |
| Molecular mechanism: |
circPVT1 acts as a ceRNA for miR-145-5p and contributes to cisplatin and pemetrexed resistance through the miR-145-5p/ABCC1 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); chemoresistance (promotes); drug resistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Western Blot |
| Clinical significance: |
High circPVT1 expression is positively related to N stage and chemotherapy insensitivity and is an independent prognostic biomarker for LAD patients; higher circPVT1 expression predicts shorter survival time. |
| Description: |
circPVT1 is up-regulated in lung adenocarcinoma tissues and cisplatin/pemetrexed-resistant A549/DR cells. Its high expression is associated with chemotherapy insensitivity and poor prognosis, and circPVT1 promotes chemotherapy resistance by acting as a ceRNA for miR-145-5p to regulate ABCC1. |
| Confidence score: |
0.8111 |