circRNA basic information
circBase ID: -
Name: hsa_circ_FN1
Synonym: circFN1
Host Gene: FN1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005133
MONDO name: endometriosis
Disease details: Endometriosis / EMS
Disease DO ID:
 289
Disease MeSH ID:
 D004715
Disease NCIt ID:
 C3014
Disease ICD11 ID:
 1838213761
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ectopic endometrial tissues; endometrial tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CD84
Associated microRNA: hsa-miR-1301-3p
Biological function: Affects immune-related activities in endometriosis by regulating CD84 via miRNA sponging.
Molecular mechanism: ceRNA mechanism: circFN1 sponges hsa-miR-1301-3p to regulate CD84.
Biological pathway or process:

immune regulation (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

In EMS ectopic tissues, circFN1 is up-regulated and may function as a ceRNA by sponging hsa-miR-1301-3p to increase CD84, contributing to immune-related dysregulation in endometriosis.
Confidence score:

0.4032
Other information
Title:

Comprehensive Analysis of RNA-Seq in Endometriosis Reveals Competing Endogenous RNA Network Composed of circRNA, lncRNA and mRNA.

Journal: Frontiers in genetics
Published: 2022
PubMed ID: 35391800
Study type:

combined biological and clinical study
Data availability: Supplementary Material (https://www.frontiersin.org/articles/10.3389/fgene.2022.828238/full#supplementary-material)
Code availability: -