| Expression pattern: |
UP |
| Associated gene: |
FLOT1 |
| Associated microRNA: |
miR-622 |
| Biological function: |
Promotes esophageal cancer cell growth and invasion and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0003855 may act as a miRNA sponge for miR-622 to regulate FLOT1 expression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
Circ_0003855 may be a new therapeutic target for EC and a future direction for EC diagnosis and treatment research. |
| Description: |
Circ_0003855 is up-regulated in Eca109 esophageal cancer cells versus normal HEEC cells. Silencing Circ_0003855 suppresses proliferation and invasion and increases apoptosis, likely by relieving miR-622 suppression and reducing FLOT1 expression, consistent with a circ_0003855/miR-622/FLOT1 regulatory axis. |
| Confidence score: |
0.4635 |