| Expression pattern: |
UP |
| Associated gene: |
Wnt3, beta-catenin, AgO2 |
| Associated microRNA: |
miR-217 |
| Biological function: |
Promotes radioresistance and suppresses radiation sensitivity; promotes proliferation, colony formation and migration; promotes EMT-like phenotype in radioresistant ESCC cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-217 and thereby relieves miR-217-mediated repression of Wnt3, activating Wnt/beta-catenin signaling to enhance radioresistance. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); EMT (promotes); proliferation (promotes); migration (promotes); ceRNA regulation (promotes); radioresistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circRNA_100367 is up-regulated in radioresistant ESCC cells and promotes radioresistance, proliferation and migration/EMT-like phenotypes. Mechanistically, it acts as a cytoplasmic sponge of miR-217, relieving repression of Wnt3 and enhancing Wnt/beta-catenin signaling; circRNA_100367 silencing increases radiosensitivity and suppresses xenograft growth under irradiation. |
| Confidence score: |
0.7767 |