| Expression pattern: |
UP |
| Associated gene: |
GBX2, ZC3H13, AGO2 |
| Associated microRNA: |
miR-1299 |
| Biological function: |
circRERE promotes HCC cell viability, growth and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
circRERE acts through miR-1299 to promote GBX2 expression and also regulates GBX2 m6A modification through ZC3H13. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); m6A modification (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; MeRIP / MeRIP-seq; Western Blot |
| Clinical significance: |
The findings suggest circRERE as a potential new target for the diagnosis and treatment of HCC. |
| Description: |
circRERE is upregulated in HCC cells and functions as an oncogenic circRNA. It promotes HCC cell viability, growth and invasion while suppressing apoptosis by enhancing GBX2 expression through miR-1299 and by modulating GBX2 m6A modification through ZC3H13. |
| Confidence score: |
0.6562 |