| Expression pattern: |
UP |
| Associated gene: |
TRAF1, UQCRC2 |
| Associated microRNA: |
miR-545-3p |
| Biological function: |
circ_0038467 promotes LPS-induced 16HBE cell injury by suppressing proliferation and facilitating apoptosis and inflammation; knockdown of circ_0038467 restores cell viability and proliferation and reduces apoptosis and inflammatory cytokine expression. |
| Molecular mechanism: |
circ_0038467 acts as a competing endogenous RNA that sponges miR-545-3p, thereby positively regulating TRAF1 expression and aggravating LPS-induced neonatal pneumonia cell injury. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0038467 was highly expressed in serum specimens of neonatal pneumonia patients and may provide a feasible curative avenue for neonatal pneumonia treatment. |
| Description: |
circ_0038467 is up-regulated in sera from neonatal pneumonia patients and in LPS-treated 16HBE cells. Functionally, circ_0038467 promotes LPS-induced bronchial epithelial cell injury by reducing proliferation and enhancing apoptosis and inflammatory cytokine expression. Mechanistically, circ_0038467 sponges miR-545-3p to increase TRAF1 expression, forming a circ_0038467/miR-545-3p/TRAF1 regulatory axis. |
| Confidence score: |
0.7936 |