| Expression pattern: |
UP |
| Associated gene: |
PFKM, AGO2 |
| Associated microRNA: |
miR-668-3p |
| Biological function: |
enhances proliferation, migration, invasion, and glycolysis of NSCLC cells; promotes tumor progression in vivo |
| Molecular mechanism: |
ceRNA mechanism: circZNF707 sponges miR-668-3p to relieve repression of PFKM, promoting glycolysis |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
CircZNF707 may provide new insights into the treatment and diagnosis of NSCLC. |
| Description: |
circZNF707 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, and glycolysis by sponging miR-668-3p to upregulate PFKM, and its knockdown suppresses tumor growth in a nude-mouse xenograft model. |
| Confidence score: |
0.8539 |