| Expression pattern: |
UP |
| Associated gene: |
HMGA2 |
| Associated microRNA: |
miR-503-5p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, invasion and EMT; accelerates gastric cancer progression. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-503-5p to upregulate HMGA2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; BrdU; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
High circ_0000267 expression was associated with increased tumor diameter and local lymph node metastasis. |
| Description: |
circ_0000267 is up-regulated in gastric cancer tissues and cell lines and is associated with larger tumor diameter and lymph node metastasis. Functionally, it promotes GC cell proliferation, migration/invasion and EMT by sponging miR-503-5p and increasing HMGA2 expression (circ_0000267/miR-503-5p/HMGA2 axis). |
| Confidence score: |
0.7657 |