| Expression pattern: |
UN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with lymph node metastasis and poor prognosis; plasma level increases at recurrence and may be useful for monitoring tumor dynamics/recurrence. |
| Molecular mechanism: |
not specified |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
High preoperative plasma circERBB2 is associated with lymph node metastasis and predicts poor relapse-free and overall survival; postoperative monitoring may help detect recurrence. |
| Description: |
This study identifies circulating circERBB2 (derived from ERBB2) as a plasma biomarker in gastric cancer. Detectable/high preoperative plasma circERBB2 is associated with lymph node metastasis and predicts worse relapse-free and overall survival. Plasma circERBB2 levels decrease after surgery and rise at recurrence, supporting its use for postoperative monitoring. |
| Confidence score: |
0.6605 |