circRNA basic information
circBase ID: hsa_circ_0006837
Name: hsa_circ_RERE
Synonym: circRERE
Host Gene: RERE
Genomic location(hg19): chr1:8555122-8617582:-
Genomic location(hg38): chr1:8495062-8557523:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal tissues
Cell lines:

HGC27; MKN74; AGS; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FBXO21
Associated microRNA: miR-424-5p
Biological function: Suppresses gastric cancer cell proliferation, migration, and invasion.
Molecular mechanism: Acts as a miRNA sponge targeting miR-424-5p, thereby regulating downstream FBXO21 to modulate malignant behaviors in gastric cancer cells.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

Low hsa_circ_0006837 expression is associated with poorer overall survival and hsa_circ_0006837 is an independent prognostic indicator in gastric cancer.
Description:

hsa_circ_0006837 (circRERE) is downregulated in gastric cancer and higher expression predicts better overall survival. Functionally, its overexpression suppresses GC cell proliferation, migration, and invasion by targeting miR-424-5p and upregulating the downstream gene FBXO21.
Confidence score:

0.7283
Other information
Title:

Hsa_circ_0006837 suppresses gastric cancer cell proliferation, migration, and invasion via the modulation of miR-424-5p.

Journal: Hereditas
Published: 2025
PubMed ID: 40405299
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -