| Expression pattern: |
UP |
| Associated gene: |
Ki-67, Vimentin |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
circTNPO1 promotes osteosarcoma cell proliferation, migration, metastasis-related behavior, and xenograft tumor growth; knockdown of circTNPO1 inhibits proliferation and migration. |
| Molecular mechanism: |
circTNPO1 acts as a sponge for miR-338-3p, downregulates miR-338-3p expression, and modulates Ki-67 and Vimentin expression to promote osteosarcoma proliferation and migration. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circTNPO1 could be a new target for osteosarcoma treatments. |
| Description: |
circTNPO1 is up-regulated in osteosarcoma cell lines compared with human osteoblast cells. It promotes osteosarcoma proliferation, migration, metastasis-related phenotypes, and xenograft tumor growth by sponging miR-338-3p and regulating Ki-67 and Vimentin expression, suggesting it may be a therapeutic target for osteosarcoma. |
| Confidence score: |
0.6479 |