| Expression pattern: |
DN |
| Associated gene: |
GNG7, Ago2 |
| Associated microRNA: |
miR-425-3p |
| Biological function: |
Inhibits proliferation, angiogenesis and glucose metabolism; promotes apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-425-3p to upregulate GNG7 expression. |
| Biological pathway or process: |
proliferation (inhibits); angiogenesis (inhibits); apoptosis (promotes); glycolysis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; EdU Staining; Colony Formation Assay; Tube Formation Assay; Western Blot; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Clinical Sample Validation; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0007099 might be a biological molecule for GC diagnosis and could be a molecular marker for GC treatment. |
| Description: |
circ_0007099 is down-regulated in gastric carcinoma and acts as a tumor suppressor. It sponges miR-425-3p to upregulate GNG7, thereby inhibiting proliferation, angiogenesis and glycolysis while promoting apoptosis, and it suppresses tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7856 |