| Expression pattern: |
DN |
| Associated gene: |
TET1 |
| Associated microRNA: |
miR-767-5p |
| Biological function: |
inhibits proliferation and invasion of enzalutamide-resistant prostate cancer cells; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circUCK2 binds miR-767-5p, reducing free miR-767-5p and increasing TET1 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; RNA Pull-Down; Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circUCK2 is down-regulated in enzalutamide-resistant prostate cancer cells and acts as a miRNA sponge for miR-767-5p, thereby increasing TET1 and suppressing proliferation and invasion. Overexpression of circUCK2 inhibits EnzR-C4-2 tumor growth in a mouse xenograft model. |
| Confidence score: |
0.6952 |