circRNA basic information
circBase ID: hsa_circ_0001136
Name: hsa_circ_ASXL1
Synonym: circASXL1
Host Gene: ASXL1
Genomic location(hg19): chr20:30954186-30956926:+
Genomic location(hg38): chr20:32366383-32369123:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer / BCa
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent normal mucosa; bladder cancer tissues; adjacent noncancerous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circASXL1 is up-regulated in bladder cancer tissues, correlates with tumor grade, tumor stage, lymph node invasion and distant metastasis, predicts tumor invasion with modest accuracy, and high expression is associated with shorter overall survival.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Bioinformatics Analysis
Clinical significance:

circASXL1 expression correlates with TNM classification and may independently predict overall survival; high expression is associated with shorter overall survival and has modest accuracy for predicting tumor invasion.
Description:

circASXL1 is a human circRNA transcribed from the ASXL1 gene locus and is significantly up-regulated in bladder cancer tissues. Its high expression correlates with tumor grade, TNM-related parameters, lymph node invasion, distant metastasis, and shorter overall survival, suggesting diagnostic and prognostic value in bladder cancer.
Confidence score:

0.6759
Other information
Title:

Expression of circular RNA circASXL1 correlates with TNM classification and predicts overall survival in bladder cancer.

Journal: International journal of clinical and experimental pathology
Published: 2017
PubMed ID: 31966702
Study type:

clinical study
Data availability: CircBase; circ2 Traits; http://www.circbase.org
Code availability: -