| Expression pattern: |
UP |
| Associated gene: |
IRF4 |
| Associated microRNA: |
miR-185-5p |
| Biological function: |
Circ_0005615 promotes multiple myeloma progression, proliferation, cell cycle progression, xenograft tumor growth, and bortezomib resistance, while inhibiting apoptosis. |
| Molecular mechanism: |
Circ_0005615 functions as a molecular sponge for miR-185-5p and positively regulates IRF4 expression, thereby mediating the miR-185-5p/IRF4 signaling cascade in multiple myeloma. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); drug resistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
circ_0005615 may have potential diagnostic and therapeutic values in multiple myeloma. |
| Description: |
Circ_0005615 is up-regulated in multiple myeloma tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, cell cycle progression, tumor growth, and bortezomib resistance while suppressing apoptosis. Mechanistically, circ_0005615 sponges miR-185-5p to upregulate IRF4, forming a circ_0005615/miR-185-5p/IRF4 regulatory axis. |
| Confidence score: |
0.7949 |