| Expression pattern: |
UP |
| Associated gene: |
onecut2 |
| Associated microRNA: |
miR-3188 |
| Biological function: |
Promotes proliferation, migration, invasion and EMT of oral squamous cell carcinoma cells; knockdown inhibits migratory and invasive capabilities. |
| Molecular mechanism: |
hsa-circRNA-0001847 functions as a miRNA sponge by adsorbing miR-3188 and regulates downstream onecut2, influencing invasion and metastasis of OSCC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; RNA Pull-Down |
| Clinical significance: |
Potential diagnostic and therapeutic target for OSCC. |
| Description: |
hsa_circ_0001847 is up-regulated in OSCC tissues and cell lines. Functional knockdown experiments indicate that it promotes OSCC proliferation, migration, invasion and EMT. Mechanistically, the study supports a ceRNA-like hsa_circ_0001847/miR-3188/onecut2 axis, suggesting potential diagnostic and therapeutic value in OSCC. |
| Confidence score: |
0.6815 |