circRNA basic information
circBase ID: hsa_circ_0014717
Name: hsa_circ_CCT3
Synonym: circ_0014717
Host Gene: CCT3
Genomic location(hg19): chr1:156290629-156304709:-
Genomic location(hg38): chr1:156320838-156334918:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

Fresh cancer tissues; pair-matched adjacent normal tissues; tumor tissues; resected tumor tissues
Cell lines:

HCT116; HT29; SW480; FHC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: p16
Associated microRNA: -
Biological function: Acts as a tumor suppressor in colorectal cancer; suppresses CRC cell proliferation and colony formation; induces G0/G1 cell cycle arrest; inhibits xenograft tumor growth; upregulates p16 expression.
Molecular mechanism: hsa_circ_0014717 represses CRC cell growth partly through upregulating p16 expression; p16 knockdown reverses hsa_circ_0014717-mediated growth inhibition.
Biological pathway or process:

proliferation (inhibits); cell cycle (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; In Vivo Animal Model; Western Blot; Survival Analysis; ROC Analysis
Clinical significance:

Downregulated in CRC tissues and cell lines; associated with TNM stage, distal metastasis, and overall survival; ROC analysis showed diagnostic potential with AUC 0.683; low expression predicted poor prognosis.
Description:

hsa_circ_0014717 is downregulated in colorectal cancer tissues and cell lines and lower expression is associated with advanced TNM stage, distal metastasis, and poorer overall survival. Functionally, hsa_circ_0014717 suppresses CRC proliferation, colony formation, cell cycle progression, and xenograft tumor growth. Mechanistically, it inhibits CRC growth at least partly by upregulating the tumor suppressor p16.
Confidence score:

0.6584
Other information
Title:

Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2018
PubMed ID: 29571246
Study type:

combined biological and clinical study
Data availability: -
Code availability: -