| Expression pattern: |
DN |
| Associated gene: |
GOLIM4 |
| Associated microRNA: |
miR-942-5p |
| Biological function: |
Circ_RNF10 inhibits breast cancer cell proliferation, migration, invasion and tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_RNF10 acts as a competing endogenous RNA sponge for miR-942-5p, thereby indirectly increasing GOLIM4 expression and suppressing breast cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; MTT; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Circ_RNF10 may become a new therapeutic target for breast cancer and may provide a new idea for early diagnosis and treatment. |
| Description: |
Circ_RNF10 (hsa_circ_0028899), derived from RNF10, is down-regulated in breast cancer tissues and cells. Restoring circ_RNF10 suppresses malignant breast cancer phenotypes by inhibiting proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_RNF10 functions as a ceRNA for miR-942-5p to upregulate GOLIM4. |
| Confidence score: |
0.7956 |