| Expression pattern: |
UP |
| Associated gene: |
AHR |
| Associated microRNA: |
miR-204-5p |
| Biological function: |
contributes to tamoxifen resistance; enhances cell viability and proliferation |
| Molecular mechanism: |
circMET upregulates AHR expression by sponging miR-204-5p, thereby promoting tamoxifen resistance of breast cancer cells |
| Biological pathway or process: |
drug resistance (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circMET was enhanced in tamoxifen-resistant samples compared with tamoxifen-sensitive samples and was presented as a potential indicator for TAM response of BC patients and a promising therapeutic target |
| Description: |
circMET is up-regulated in tamoxifen-resistant breast cancer cells and clinical tamoxifen-resistant samples. It promotes tamoxifen resistance, cell viability, and proliferation by acting through the miR-204-5p/AHR axis, suggesting potential value as an indicator of tamoxifen response and a therapeutic target. |
| Confidence score: |
0.7507 |