| Expression pattern: |
UP |
| Associated gene: |
HSP90 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
circHIPK2 promotes CRC progression, cell proliferation, EdU-positive cell rate, and migration, and its downregulation inhibits these malignant phenotypes. |
| Molecular mechanism: |
circHIPK2 is mainly cytoplasmic and regulates the miR-485-5p/HSP90 axis; circHIPK2 suppresses miR-485-5p, induces HSP90 expression, and promotes CRC tumor growth and progression via HSP90 ubiquitination. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ubiquitination (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RT-qPCR; RNA-seq; Microarray; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Western Blot; IF (Immunofluorescence); Survival Analysis |
| Clinical significance: |
circHIPK2 is upregulated in CRC patients, high circHIPK2 expression is associated with lower overall survival and disease-free survival, and circHIPK2 is considered a promising biomarker for CRC diagnosis and prognosis and a potential therapeutic target. |
| Description: |
circHIPK2 is upregulated in CRC tissues and cell lines and high expression is associated with poorer overall and disease-free survival. Functionally, circHIPK2 promotes CRC cell proliferation and migration, likely through a cytoplasmic circHIPK2/miR-485-5p/HSP90 regulatory mechanism involving HSP90 ubiquitination. The study proposes circHIPK2 as a potential diagnostic/prognostic biomarker and therapeutic target for CRC. |
| Confidence score: |
0.7357 |