circRNA basic information
circBase ID: hsa_circ_0058063
Name: -
Synonym: circ_0058063
Host Gene: -
Genomic location(hg19): chr2:216177220-216213972:+
Genomic location(hg38): chr2:215312497-215349249:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; neighboring normal breast tissues
Cell lines:

MCF-7; MDA-MB-231; MDA-MB-468; MCF-10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: DLGAP5, Ago2
Associated microRNA: miR-557
Biological function: promotes proliferation and migration; inhibits apoptosis; promotes tumor growth
Molecular mechanism: circ_0058063 sponges miR-557 to upregulate DLGAP5 (ceRNA mechanism).
Biological pathway or process:

proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; CCK8; Transwell Assay; In Vivo Animal Model; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection
Clinical significance:

-
Description:

circ_0058063 is up-regulated in breast cancer tissues/cells and promotes proliferation, migration and tumor growth while inhibiting apoptosis. It functions mainly in the cytoplasm as a miRNA sponge for miR-557, thereby relieving miR-557-mediated repression and upregulating DLGAP5.
Confidence score:

0.6959
Other information
Title:

circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2024
PubMed ID: 37334578
Study type:

combined biological and clinical study
Data availability: This article contains all of the data that were created or examined during this investigation.
Code availability: -