circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer patient tissues; healthy para-carcinoma tissues; healthy adjacent ones; human breast tissues
Cell lines:

LO2; MCF-10A; MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker candidate; circMTO1 was measured at lower levels in breast cancer tissues than in healthy tissues and was evaluated for distinguishing breast cancer patients from healthy individuals.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circMTO1 showed lower levels in breast cancer tissues than in healthy tissues and diagnostic performance for distinguishing breast cancer patients from healthy individuals; AUC value of the single-molecule biosensor was 1.
Description:

This study used a ligation-controlled single-molecule biosensor and qRT-PCR to measure circMTO1 in human cells and breast tissues. circMTO1 showed lower levels in breast cancer tissues than in healthy tissues and was evaluated as a diagnostic marker with ROC analysis.
Confidence score:

0.4187
Other information
Title:

Construction of a Ligation-Controlled Single-Molecule Biosensor for Simultaneous Measurement of Multiple Cancer-Related circRNAs in Clinical Tissues.

Journal: Analytical chemistry
Published: 2025
PubMed ID: 40329757
Study type:

combined biological and clinical study
Data availability: Supporting Information available at https://pubs.acs.org/doi/10.1021/acs.analchem.5c00527
Code availability: -