circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; blood samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential blood biomarker for CRC; associated with increased circular-to-linear ratio in peripheral blood of patients with CRC.
Molecular mechanism: The study suggests increased circularization of HIPK3 transcripts in CRC peripheral blood, but does not experimentally define a molecular mechanism for circHIPK3.
Biological pathway or process:

other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

Potential blood biomarker for CRC progression, screening, diagnosis, and treatment.
Description:

In this study, circHIPK3 was measured in peripheral blood from CRC patients and healthy controls. Its absolute expression was higher but not statistically significant, while the circHIPK3:linHIPK3 ratio was significantly increased, suggesting elevated circularization and potential value as a blood biomarker for CRC.
Confidence score:

0.2995
Other information
Title:

Evaluation of CD73, PD-1, circHIPK3, and circNRIP1 expression in the peripheral blood of patients with colorectal cancer.

Journal: Laboratory medicine
Published: 2025
PubMed ID: 40505000
Study type:

clinical study
Data availability: circBase (http://circbase.org/)
Code availability: -