| Expression pattern: |
UP |
| Associated gene: |
ERK, P38 |
| Associated microRNA: |
- |
| Biological function: |
promotes cervical cancer cell proliferation, migration, and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
activates MAPK signaling (increased phosphorylation of ERK and P38) in cervical cancer cells |
| Biological pathway or process: |
MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
may serve as a potential therapeutic target for patients with CC |
| Description: |
hsa_circ_0003204 is up-regulated in cervical cancer tissues/cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration and invasion and increases apoptosis, while overexpression has the opposite effects and enhances xenograft tumor growth, associated with activation of MAPK signaling (increased p-ERK and p-P38). |
| Confidence score: |
0.7523 |