circRNA basic information
circBase ID: hsa_circ_0003528
Name: -
Synonym: circ_0003528
Host Gene: -
Genomic location(hg19): chr5:134032815-134044578:+
Genomic location(hg38): chr5:134697125-134708888:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent normal tissues; non-tumor liver tissue
Cell lines:

HepG2; HUH7; THLE-2; HL-7702
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: XIAP
Associated microRNA: miR-212-3p
Biological function: promotes HCC cell viability/aggressiveness and tumor growth; inhibits apoptosis
Molecular mechanism: circ_0003528 sponges miR-212-3p to regulate XIAP (ceRNA axis)
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
H
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; MTT; TUNEL; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation
Clinical significance:

-
Description:

circ_0003528 is up-regulated in HCC tissues/cells and mainly localized in the cytoplasm. Its knockdown reduces HCC cell viability, increases apoptosis, and suppresses xenograft tumor growth, functioning through a ceRNA mechanism by sponging miR-212-3p to regulate XIAP.
Confidence score:

0.7486
Other information
Title:

Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis.

Journal: Bioengineered
Published: 2022
PubMed ID: 35484994
Study type:

combined biological and clinical study
Data availability: GSE97332
Code availability: -