| Expression pattern: |
UP |
| Associated gene: |
FGFR1 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration and invasion; facilitates cell cycle progression; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1294 to increase FGFR1 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ_0000885 expression was positively correlated with the TNM stage of OS patients. |
| Description: |
circ_0000885 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, and cell-cycle progression) as well as tumor growth in vivo. Mechanistically, it functions as a ceRNA by sponging miR-1294 to increase FGFR1 expression. |
| Confidence score: |
0.6542 |