| Expression pattern: |
UP |
| Associated gene: |
ENO1, Ago2 |
| Associated microRNA: |
miR-22-3p |
| Biological function: |
promotes glycolysis, proliferation, migration, EMT and tumor growth/metastasis; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ-ENO1 sponges miR-22-3p to upregulate ENO1 (host gene) expression |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes); metastasis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Transfection; Western Blot; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; TUNEL; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation |
| Clinical significance: |
circ-ENO1 as a potential biomarker/therapeutic target for LUAD |
| Description: |
circ-ENO1 (circ-0000013) is up-regulated in LUAD tissues and cell lines and promotes glycolysis and malignant phenotypes (proliferation, migration, EMT, tumor growth/metastasis) while suppressing apoptosis. Mechanistically, it localizes mainly in the cytoplasm and functions as a ceRNA that sponges miR-22-3p to upregulate its host gene ENO1, enhancing glycolysis and LUAD progression. |
| Confidence score: |
0.8401 |