| Expression pattern: |
UP |
| Associated gene: |
NSUN5 |
| Associated microRNA: |
- |
| Biological function: |
circSOD2 was identified as an NSUN5-regulated m5C-modified circRNA elevated in ccRCC tumors and metastatic lesions; no direct functional phenotype was reported for circSOD2. |
| Molecular mechanism: |
NSUN5 positively regulates both m5C modification and expression of circSOD2; downstream functional mechanism was not further characterized. |
| Biological pathway or process: |
other pathway/process (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RT-qPCR; RNA-seq; Microarray; MeRIP / MeRIP-seq; Bioinformatics Analysis |
| Clinical significance: |
circSOD2 was elevated in ccRCC tumors and metastatic lesions, but the article did not report a circSOD2-specific clinical biomarker conclusion. |
| Description: |
circSOD2 was identified as an up-regulated, NSUN5-regulated m5C-modified circRNA in ccRCC. The study did not further validate circSOD2-specific functional mechanisms beyond expression and m5C regulation. |
| Confidence score: |
0.413 |