| Expression pattern: |
UP |
| Associated gene: |
IL6R, RIG-I / RIG‐I |
| Associated microRNA: |
miR‐1287‐5p |
| Biological function: |
Promotes COVID-19 cytokine storm; increases IL6R and RIG-I expression in SARS-CoV-2 infection. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) and sponges hsa-miR-1287-5p, associated with increased IL6R and RIG-I (correlation-supported). |
| Biological pathway or process: |
JAK/STAT (other); PI3K/AKT (other); ceRNA regulation (promotes); inflammation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Higher hsa_circ_0004812 expression is associated with symptomatic/severe COVID-19 compared with negative controls and is higher than asymptomatic cases; suggested as a potential target for understanding/identifying/treating COVID-19. |
| Description: |
hsa_circ_0004812 is up-regulated in PBMCs from COVID-19 patients, especially symptomatic cases. It is proposed to act as a ceRNA that sponges hsa-miR-1287-5p, associated with increased IL6R and RIG-I expression and involvement of JAK/STAT and PI3K/AKT-related inflammatory signaling in COVID-19 cytokine storm. |
| Confidence score: |
0.348 |