| Expression pattern: |
UP |
| Associated gene: |
USF1 |
| Associated microRNA: |
- |
| Biological function: |
promotes chemoresistance to cisplatin, promotes immune escape, and promotes tumorigenesis (proliferation, migration, invasion) in cervical cancer cells |
| Molecular mechanism: |
USF1 transcriptionally induces circPRDM4 expression; the USF1/circPRDM4 axis regulates immune escape and tumorigenesis in chemoresistant cervical cancer cells |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); immune regulation (other); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; ELISA; IF (Immunofluorescence); ChIP / ChIP-seq; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPRDM4 is up-regulated in cisplatin-chemoresistant cervical cancer cells and promotes chemoresistance, immune escape, and malignant phenotypes (proliferation, migration, invasion). USF1 transcriptionally induces circPRDM4, forming a USF1/circPRDM4 axis that drives these behaviors. |
| Confidence score: |
0.7735 |