circRNA basic information
circBase ID: hsa_circ_0002984
Name: -
Synonym: circ_0002984
Host Gene: hsa-miR-181b-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: VSMCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-181b-5p
Biological function: Circ_0002984 silencing inhibited ox-LDL-induced proliferation and migration in VSMCs.
Molecular mechanism: hsa-miR-181b-5p was a target of circ_0002984, and hsa-miR-181b-5p inhibition counteracted the suppressing effects of circ_0002984 downregulation on proliferation and migration in ox-LDL-stimulated VSMCs. Additionally, VEGFA was a downstream target of hsa-miR-181b-5p and VEGFA upregulation abolished the suppressive influence of hsa-miR-181b-5p on proliferation and migration in ox-LDL-exposed VSMCs. Furthermore, circ_0002984 depletion blocked phosphatidylinositol 3 kinase-AKT signaling pathway by regulating hsa-miR-181b-5p and VEGFA.
Survival: -
Supported No.:
 1
Description:

Circ_0002984 downregulation suppressed cell proliferation and migration by regulating miR-181b-5p/VEGFA axis and phosphatidylinositol 3 kinase-AKT pathway in ox-LDL-stimulated VEGFA, providing a new mechanism for AS pathogenesis.
Other information
Title:

Circular RNA circ_0002984 Promotes Cell Proliferation and Migration by Regulating miR-181b-5p/Vascular Endothelial Growth Factor Axis and PI3K-AKT Signaling Pathway in Oxidized Low-Density Lipoprotein-Treated Vascular Smooth Muscle Cells.

Journal: J Cardiovasc Pharmacol
Published: 2021/12/27
PubMed ID: 34954748