| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Probably plays a role in the initiation of gastric cancer; may serve as a potential biomarker for gastric cancer screening; expression is associated with lymphatic metastasis and CA19-9. |
| Molecular mechanism: |
Unknown; the study suggests possible involvement in gastric cancer initiation but does not experimentally define a molecular mechanism. |
| Biological pathway or process: |
metastasis (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
May be a potential gastric cancer biomarker; has potential diagnostic value for screening of gastric cancer and gastric cancer metastasis; expression levels were associated with CA19-9 and lymphatic metastasis. |
| Description: |
This study reports that hsa_circ_0074362 is significantly downregulated in gastric cancer tissues, gastric cancer cell lines, and gastritis tissues. Its expression is associated with CA19-9 and lymphatic metastasis, and ROC analysis suggests potential diagnostic biomarker value for gastric cancer screening, although the molecular mechanism was not experimentally defined. |
| Confidence score: |
0.6238 |