| Expression pattern: |
DN |
| Associated gene: |
PTEN, PI3K, Akt, MICA, AGO2 |
| Associated microRNA: |
miR-934 |
| Biological function: |
Suppresses proliferation, invasion, and migration of breast cancer cells and enhances NK cell-mediated cytotoxicity; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-934 to regulate PTEN and suppress PI3K/Akt/MICA signaling. |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); immune regulation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; ELISA; Western Blot; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
Higher circRNF10 level is related to a favorable prognosis in breast cancer. |
| Description: |
circRNF10 (hsa_circ_0028899) is down-regulated in breast cancer and higher expression predicts better prognosis. It suppresses breast cancer cell proliferation/migration/invasion and enhances NK-cell cytotoxicity by sponging miR-934, thereby upregulating PTEN and inhibiting PI3K/AKT/MICA signaling; it also reduces tumor growth in xenografts. |
| Confidence score: |
0.8684 |