| Expression pattern: |
UP |
| Associated gene: |
MADD, AGO2 |
| Associated microRNA: |
miR-1197 |
| Biological function: |
promotes cell proliferation, migration, invasion and tumorigenesis; inhibits apoptosis; promotes metastasis |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1197 to promote MADD expression (miR-1197 binds the 3ʹUTR of MADD). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0000429 is up-regulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation, migration/invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it predominantly localizes in the cytoplasm and functions as a ceRNA by sponging miR-1197, thereby increasing MADD expression. |
| Confidence score: |
0.7635 |