| Expression pattern: |
DN |
| Associated gene: |
FKBP5, PHLPP1, AKT, AKT1 |
| Associated microRNA: |
miR-122-5p |
| Biological function: |
Inhibits prostate cancer cell proliferation, migration and invasion; promotes apoptosis; inhibits testosterone/DHT synthesis; enhances abiraterone sensitivity. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-122-5p to upregulate FKBP5, activating FKBP5/PHLPP1 and inhibiting AKT phosphorylation, thereby suppressing PCa progression and increasing abiraterone sensitivity. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); PI3K/AKT/mTOR (inhibits); ceRNA regulation (promotes); drug resistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; ELISA |
| Clinical significance: |
The expression of circ_0001047 in vivo was negatively related to testosterone secretion and negatively related to PSA expression (not significant for PSA). |
| Description: |
circ_0001047 is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-122-5p to increase FKBP5 (and FKBP5/PHLPP1 signaling), thereby inhibiting AKT phosphorylation and reducing malignant phenotypes, while enhancing abiraterone sensitivity. |
| Confidence score: |
0.7595 |