| Expression pattern: |
UP |
| Associated gene: |
SOX5, TNF-alpha, IL-6 |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
Promotes IL-1beta-induced chondrocyte injury by decreasing cell proliferation and increasing apoptosis and inflammation. |
| Molecular mechanism: |
circSEC24A acts as a molecular sponge of miR-142-5p to regulate SOX5 expression in chondrocytes. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); inflammation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
providing a promising target for gene therapy |
| Description: |
circSEC24A is up-regulated in OA cartilage tissues, OA chondrocytes, and IL-1beta-treated chondrocytes. It aggravates OA-like chondrocyte injury by inhibiting proliferation and promoting apoptosis and inflammatory factor expression, acting through a circSEC24A/miR-142-5p/SOX5 ceRNA axis. |
| Confidence score: |
0.7032 |