| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-124 |
| Biological function: |
circHIPK3 promotes OSCC cell proliferation; silencing circHIPK3 inhibits proliferation of CAL27 and SCC15 cells and may participate in OSCC occurrence and development. |
| Molecular mechanism: |
circHIPK3 may act through regulation of miR-124 expression; down-regulation of miR-124 partially rescues the proliferation-inhibitory phenotype induced by circHIPK3 knockdown. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8 |
| Clinical significance: |
circHIPK3 expression was closely associated with TNM stage and tumor grades; circHIPK3 may be a potential target for early diagnosis, prognosis judgment and targeted therapy in OSCC. |
| Description: |
circHIPK3 is up-regulated in OSCC tissues and OSCC cell lines. The study indicates that circHIPK3 promotes CAL27 and SCC15 cell proliferation, at least partly through regulation of miR-124, and its expression is associated with TNM stage and tumor grade. |
| Confidence score: |
0.4862 |