| Expression pattern: |
UP |
| Associated gene: |
MYH9 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, EMT, exosome-mediated malignant phenotypes, and tumor growth in vivo; inhibits apoptosis. |
| Molecular mechanism: |
circ_0000395 acts as a ceRNA/miRNA sponge by sequestering miR-432-5p, thereby elevating MYH9 expression; CRC cell-derived exosomal circ_0000395 also promotes malignant phenotypes. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; H&E Staining; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target for CRC |
| Description: |
In this study, hsa_circ_0000395/circ_0000395 was up-regulated in CRC tissues, CRC cell lines, and CRC cell-derived exosomes. It promoted CRC progression by enhancing proliferation, migration, invasion, EMT and tumor growth while suppressing apoptosis. Mechanistically, circ_0000395 sponged miR-432-5p to increase MYH9 expression, and exosomal circ_0000395 contributed to malignant phenotypes of recipient CRC cells. |
| Confidence score: |
0.7898 |