| Expression pattern: |
UP |
| Associated gene: |
NFIB, FAM71F2 |
| Associated microRNA: |
miR-326 |
| Biological function: |
Promotes oxaliplatin resistance, tumor growth, proliferation, invasion, migration, and malignant progression, and inhibits apoptosis in OXA-resistant colorectal cancer cells. |
| Molecular mechanism: |
Circ_0082182 acts as a miR-326 sponge to upregulate NFIB expression, thereby promoting oxaliplatin resistance and malignant progression in colorectal cancer. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); invasion (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Circ_0082182 was overexpressed in OXA-resistant CRC tissues and may be used to elevate chemosensitivity in OXA-resistant CRC cells via expression knockdown. |
| Description: |
Circ_0082182 is up-regulated in oxaliplatin-resistant colorectal cancer tissues and cells. It promotes oxaliplatin resistance and malignant progression by sponging miR-326 and increasing NFIB expression, while circ_0082182 knockdown enhances chemosensitivity and suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.786 |