| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
premature miR-200c, miR-200c |
| Biological function: |
Promotes OS cell proliferation and glucose uptake; regulates tumor growth but not tumor metastasis; suppresses miR-200c maturation. |
| Molecular mechanism: |
CircCSPP1 directly interacts with premature miR-200c and suppresses miR-200c maturation, likely by sponging premature miR-200c in the nucleus and suppressing its transport to the cytoplasm. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Bioinformatics Analysis; Transfection; BrdU |
| Clinical significance: |
CircCSPP1 expression in OS tissues was closely correlated with patients' tumor size and blood glucose, suggesting it may mainly regulate tumor growth in OS and may serve as a potential target to treat OS. |
| Description: |
This study identifies circCSPP1 as an up-regulated oncogenic circRNA in human osteosarcoma. CircCSPP1 directly interacts with premature miR-200c, suppresses miR-200c maturation, and thereby promotes OS cell proliferation and glucose uptake. Clinically, circCSPP1 expression correlates with tumor size and blood glucose, suggesting potential relevance to tumor growth and metabolic regulation. |
| Confidence score: |
0.6432 |