circRNA basic information
circBase ID: hsa_circ_0020093
Name: hsa_circ_ATRNL1
Synonym: circATRNL1
Host Gene: ATRNL1
Genomic location(hg19): chr10:116879948-116889297:+
Genomic location(hg38): chr10:115120184-115129535:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

ovarian cancer tissues; normal ovarian tissues
Cell lines:

A2780; SKOV3; SW626; IOSE80; HEK-293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: 131 aa protein
Associated microRNA: -
Biological function: inhibits proliferation; inhibits migration; inhibits invasion
Molecular mechanism: encodes a 131 aa protein via ORF/IRES
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Sanger Sequencing; FISH / smFISH; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

circATRNL1 (hsa_circ_0020093) is down-regulated in ovarian cancer tissues and suppresses ovarian cancer cell proliferation, migration, and invasion. Mechanistically, it has protein-coding capacity and encodes a 131-aa protein driven by an IRES/ORF feature validated by FLAG-tag western blot.
Confidence score:

0.7296
Other information
Title:

CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein.

Journal: Frontiers in genetics
Published: 2022
PubMed ID: 35281849
Study type:

combined biological and clinical study
Data availability: GSE192410
Code availability: -