| Expression pattern: |
UP |
| Associated gene: |
CCNB1, p21, caspase 3, caspase 9 |
| Associated microRNA: |
miR-26b-5p |
| Biological function: |
circPVT1 promotes OS cell viability, proliferation, invasion, migration, tumor growth and lung metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circPVT1 functions as a ceRNA by sponging miR-26b-5p, thereby indirectly regulating CCNB1 expression and downstream cell-cycle/apoptosis-related proteins. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
circPVT1 might be used as a target for OS treatment. |
| Description: |
This study reports that circPVT1 is up-regulated in osteosarcoma cells and tissues. Functionally, circPVT1 promotes OS tumorigenesis and metastasis by sponging miR-26b-5p and regulating CCNB1, thereby enhancing proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis. |
| Confidence score: |
0.7053 |