circRNA basic information
circBase ID: hsa_circ_0012152
Name: hsa_circ_RNF220
Synonym: circRNF220
Host Gene: RNF220
Genomic location(hg19): chr1:44877652-44878394:+
Genomic location(hg38): chr1:44411980-44412722:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; serum
Cell lines:

HS-5; THP-1; MV4-11; KG-1; HL-60; AML2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: miR-330-5p
Biological function: circRNF220 promotes AML cell proliferation, cell cycle progression, invasion, and glycolytic metabolism, and inhibits apoptosis.
Molecular mechanism: circRNF220 acts as a sponge for miR-330-5p to up-regulate SOX4 expression via a circRNF220/miR-330-5p/SOX4 ceRNA axis.
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Bioinformatics Analysis
Clinical significance:

circRNF220 expression was analyzed in relation to clinicopathological parameters of AML patients, but no clear diagnostic or prognostic conclusion for circRNF220 was reported.
Description:

circRNF220 is up-regulated in AML serum samples and AML cell lines. It promotes AML cell proliferation, cell cycle progression, invasion, and glycolysis while suppressing apoptosis, mainly through sponging miR-330-5p to increase SOX4 expression.
Confidence score:

0.8206
Other information
Title:

CircRNF220 plays a pathogenic role to facilitate cell progression of AML in vitro via sponging miR-330-5p to induce upregulation of SOX4.

Journal: Histology and histopathology
Published: 2022
PubMed ID: 35611720
Study type:

combined biological and clinical study
Data availability: GSE94591; TCGA database (http://gepia.cancer-pku.cn/detail.php?gene=SOX4); Supplementary file 1
Code availability: -