| Expression pattern: |
DN |
| Associated gene: |
HIF1AN |
| Associated microRNA: |
miR-181a-5p |
| Biological function: |
circSLC8A1 suppresses HKFs proliferation, migration and extracellular matrix deposition, and promotes apoptosis, thereby inhibiting keloid formation. |
| Molecular mechanism: |
circSLC8A1 acts as a miR-181a-5p sponge to indirectly upregulate HIF1AN expression through a ceRNA mechanism. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
circSLC8A1 might serve as a novel therapeutic target for keloids. |
| Description: |
circSLC8A1 is down-regulated in keloid tissues and human keloid fibroblasts. Its overexpression inhibits fibroblast proliferation, migration and ECM deposition while promoting apoptosis, mainly by sponging miR-181a-5p to upregulate HIF1AN. The study suggests circSLC8A1 as a potential therapeutic target for keloids. |
| Confidence score: |
0.7981 |