| Expression pattern: |
UP |
| Associated gene: |
USP22 |
| Associated microRNA: |
miR-30e-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, and invasion (oncogenic role). |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-30e-5p, relieving repression of USP22 and increasing USP22 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Potential prognostic prediction biomarker and therapeutic target for NSCLC. |
| Description: |
circFAT1(e2) is up-regulated in NSCLC tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-30e-5p to increase USP22 expression, thereby promoting proliferation, migration/invasion and metastasis-related phenotypes in NSCLC cells. |
| Confidence score: |
0.6369 |