| Expression pattern: |
UP |
| Associated gene: |
ABCC1 |
| Associated microRNA: |
miR-508-3p |
| Biological function: |
CircSETDB1 promotes paclitaxel resistance, cell viability, proliferation and cell cycle progression, and inhibits apoptosis in Ptx-resistant ovarian cancer cells; circSETDB1 knockdown enhances paclitaxel sensitivity in vitro and in vivo. |
| Molecular mechanism: |
CircSETDB1 acts as a miR-508-3p sponge to regulate ABCC1 expression, thereby promoting paclitaxel resistance in ovarian cancer. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSETDB1 expression is associated with poor prognosis in ovarian cancer patients and circSETDB1 is related to chemotherapy response and recurrence. |
| Description: |
CircSETDB1 is up-regulated in paclitaxel-resistant ovarian cancer tissues and cells and high expression is associated with poor prognosis. Functionally, circSETDB1 promotes paclitaxel resistance, proliferation and cell-cycle progression while suppressing apoptosis. Mechanistically, it functions as a cytoplasmic miR-508-3p sponge to increase ABCC1 expression, forming a circSETDB1/miR-508-3p/ABCC1 axis that contributes to paclitaxel resistance. |
| Confidence score: |
0.8353 |