| Expression pattern: |
UP |
| Associated gene: |
RAB7A, PSME3 |
| Associated microRNA: |
miR-578 |
| Biological function: |
promotes migration, invasion and proliferation; inhibits apoptosis; promotes tumor growth and metastasis |
| Molecular mechanism: |
ceRNA mechanism: circGPC3 sponges miR-578 to upregulate downstream targets RAB7A and PSME3 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Transfection; RNA Pull-Down; Luciferase Reporter Assay; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
High circGPC3 expression is associated with advanced TNM stage and lymph node metastasis and predicts worse overall survival; circGPC3 served as an independent risk factor for OS. |
| Description: |
circGPC3 is upregulated in hepatocellular carcinoma and promotes proliferation, migration, invasion, EMT-like changes, and metastasis while inhibiting apoptosis. It functions mainly as a ceRNA by sponging miR-578 to increase expression of the downstream targets RAB7A and PSME3, and high circGPC3 expression is associated with worse overall survival. |
| Confidence score: |
0.8802 |