| Expression pattern: |
DN |
| Associated gene: |
CPEB3 |
| Associated microRNA: |
miR-421 |
| Biological function: |
circ_ITCH acts as a tumor-suppressive circRNA in hepatocellular carcinoma under lidocaine exposure; its knockdown weakens lidocaine-induced suppression of proliferation, migration, and invasion, reduces lidocaine-induced apoptosis, and increases xenograft tumor growth. |
| Molecular mechanism: |
circ_ITCH competitively binds miR-421 to up-regulate CPEB3, thereby mediating the inhibitory effect of lidocaine on hepatocellular carcinoma development. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; MTT; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
Low circ_ITCH expression was observed in hepatocellular carcinoma tissues; prior evidence cited by the authors links low circ_ITCH expression with increased patient risk, but this study did not perform prognostic validation for circ_ITCH. |
| Description: |
circ_ITCH is down-regulated in hepatocellular carcinoma tissues and cells and is restored by lidocaine treatment. In lidocaine-treated HCC models, circ_ITCH suppresses proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis, at least partly through the circ_ITCH/miR-421/CPEB3 ceRNA axis. |
| Confidence score: |
0.742 |